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endoplasmic reticulum stress ers inhibitor 4 pba  (MedChemExpress)
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Inhibition of ER stress <t>with</t> <t>4-PBA</t> can significantly improve liver injury caused by ischemia-reperfusion in mice. (A) The relative mRNA levels of GRP78 and CHOP genes in the sham, 4-PBA (20 mg/kg), HIRI-6h, and HIRI-6h+4-PBA (20 mg/kg) groups. (B) The serum ALT and AST levels were detected in each group. (C) The histopathological features of the liver were observed in each group by H&E staining. Black arrows indicated the area of liver cell necrosis. (D) The cell apoptosis of liver tissues in each group were detected by TUNEL staining. The white arrow marks the area where apoptotic cells are located. (E) The mRNA expression levels of liver injury-related genes were measured by qRT-PCRs in each group. (F) The mRNA expression levels of liver inflammation-related genes were analyzed by qRT-PCRs in each group. The results were obtained from at least three independent experiments. Values are presented as mean ± SEM. ** p < 0.05, ** p < 0.01 vs. the HIRI-6h group.
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Inhibition of ER stress with 4-PBA can significantly improve liver injury caused by ischemia-reperfusion in mice. (A) The relative mRNA levels of GRP78 and CHOP genes in the sham, 4-PBA (20 mg/kg), HIRI-6h, and HIRI-6h+4-PBA (20 mg/kg) groups. (B) The serum ALT and AST levels were detected in each group. (C) The histopathological features of the liver were observed in each group by H&E staining. Black arrows indicated the area of liver cell necrosis. (D) The cell apoptosis of liver tissues in each group were detected by TUNEL staining. The white arrow marks the area where apoptotic cells are located. (E) The mRNA expression levels of liver injury-related genes were measured by qRT-PCRs in each group. (F) The mRNA expression levels of liver inflammation-related genes were analyzed by qRT-PCRs in each group. The results were obtained from at least three independent experiments. Values are presented as mean ± SEM. ** p < 0.05, ** p < 0.01 vs. the HIRI-6h group.

Journal: Frontiers in Pharmacology

Article Title: Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice

doi: 10.3389/fphar.2025.1519497

Figure Lengend Snippet: Inhibition of ER stress with 4-PBA can significantly improve liver injury caused by ischemia-reperfusion in mice. (A) The relative mRNA levels of GRP78 and CHOP genes in the sham, 4-PBA (20 mg/kg), HIRI-6h, and HIRI-6h+4-PBA (20 mg/kg) groups. (B) The serum ALT and AST levels were detected in each group. (C) The histopathological features of the liver were observed in each group by H&E staining. Black arrows indicated the area of liver cell necrosis. (D) The cell apoptosis of liver tissues in each group were detected by TUNEL staining. The white arrow marks the area where apoptotic cells are located. (E) The mRNA expression levels of liver injury-related genes were measured by qRT-PCRs in each group. (F) The mRNA expression levels of liver inflammation-related genes were analyzed by qRT-PCRs in each group. The results were obtained from at least three independent experiments. Values are presented as mean ± SEM. ** p < 0.05, ** p < 0.01 vs. the HIRI-6h group.

Article Snippet: Endoplasmic reticulum stress (ERS) inhibitor 4-PBA (Cas no. HY-A0281) was purchased from MedChemExpress Co., Ltd. (MCE, United States).

Techniques: Inhibition, Staining, TUNEL Assay, Expressing